Endocrine Abstracts

The work was initiated to comparatively study pregnancy outcomes in patients with type I diabetes mellitus (DMI) with self-control skills and without them.We examined 50 patients with DMI aged from 20 to 29 (mean age 24±3.2 years) ranging from those with newly diagnosed disease to those with DMI duration under 12 years. Glycemia and HBA1c levels were measured to assess carbohydrate metabolism.40 patients with planned pregnancy...

Objectives: To assess current clinical practice in children aged 0–5.99 years with Type I Diabetes Mellitus (T1DM).Methods: All paediatric diabetes centres (n=17) within a single UK region were asked to provide retrospective data for the year ending 01/12/07. 15 (88%) centres responded and provided data for each child on presentation, initial and current insulin regimens. Outcome measures were HbA1c, and acute hospital admissions post-diagnos...

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with Cushing’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

Introduction: Idiopathic calcification of basal ganglia (Fahr’s syndrome) is a rare pathology, mostly incidental finding or familial origin, characterized by cognitive, behavioural and motor impairment, as well as by metabolic changes, such as primary hypoparathyroidism.Report: We report a case of a 59-years old white lady who was referred to our clinic for an evaluation due to suspected Fahr’s syndrome. She had a 20 years long history of moder...

Introduction: Deranged mitochondrial biogenesis has been linked to obesity with or without type 2 diabetes but this association has not been reported in non obese type 2 diabetes subjects. This study attempts to identify the various alterations of mitochondrial biogenesis in adipose tissue in obese and non obese type 2 diabetes subjects.Methods & Design: Since type 2 diabetes is associated with elevated serum leptin and depressed serum adiponectin le...

Objective: Insulin-like growth factor-II (IGF-II), a critical regulator of placental development, enhances proliferation and survival of human cytotrophoblasts by signalling through the IGF-1 receptor (IGF-1R). Excess IGF-II binds to IGF-2R, which mediates its transport to the lysosomes for degradation. Although considered to act solely as an IGF-II clearance receptor, IGF-2R has been implicated in mediating IGF-II-stimulated migration and invasion in trophoblast. We therefore...

A 73-year-old woman presented with hypoglycaemic collapse and a capillary blood sugar of 0.7 mmol/l and required continuous intravenous dextrose to maintain euglycaemia. There was two-week history of night sweats and overnight snacking. One year previous, the patient had been diagnosed with a gastric adenocarcinoma and had undergone a sub-total gastrectomy and chemo-radiotherapy. Physical examination was unremarkable. Liver function was normal except an elevated alkaline phosp...

Insulin resistance is possibly playing an underlying pathogenic role in the polycystic ovary syndrome (PCOS) and although is not a part of its definition, it appears in 50-90% of PCOS women. Polycystic ovary syndrome is also frequently associated with obesity; women suffering of PCOS seem to be at a great risk of developing a metabolic syndrome.Objectives: The aim of our study was to determine the prevalence of the metabolic syndrome in a population of 4...

Polycystic Ovarian Syndrome (PCOS) is the most common cause of menstrual and reproductive disorders in women of reproductive age. It is the leading cause of female infertility, up to 15%. Women with PCOS and their hormonal status marked in immune-enzyme analysis under chronic stress conditions and without it were the subject of interest. The role of chronic stress in development of many diseases is well-known. In patients with PCOS dopamine content depends on pathogenic form o...

Hydrocortisone reveals its action by activation of transcription of specific genes that is achieved by binding of hormones nuclear receptors (NRs) to cognate sites on DNA and recruiting coactivators of basal transcription machinery. NRs are able to overcome restricting conformation of chromatin by altering chromatin-remodeling machinery (chromatin-remodeling protein complexes, histone and nonhistone modifying enzymes). However, a possibility arise that genomic DNA accessibilit...